Pepto-Bismol is an over-the-counter medicine used to treat digestive symptoms such as nausea, diarrhea, and heartburn.

It contains bismuth salicylate, which coats the lining of the stomach and intestines to reduce inflammation and kill bacteria that cause gastrointestinal problems.

Although Pepto-Bismol is effective in treating colic, many people wonder how long Pepto-Bismol stays in their system. This article explains how Pepto-Bismol works, its half-life, and how long it takes to clear your body.

How does Pepto-Bismol work?

Pepto-Bismol Bismuth subsalicylate is a mixture of bismuth and salicylic acid. Bismuth subsalicylate works by coating the lining of the stomach and intestines, reducing inflammation and killing the bacteria that cause stomach ulcers. The salicylic acid in aspirin reduces pain and fever.

Factors that affect how long Pepto-Bismol stays in your system

Several factors can affect how long Pepto-Bismol stays in your system.

dose size

How long the effects of Pepto-Bismol last depends on your dose. Drugs take a long time to clear from the body. The recommended dose for adults and children 12 years and older is 2 tablets or 2 tablespoons with liquid, up to 8 times every 30-60 minutes. It is essential to follow the recommended dosage to avoid side effects.


The shelf life of Pepto-Bismol affects how long it stays in your system. In general, older adults may take longer to eliminate medications due to decreased kidney and liver function. Children may take longer to eliminate the drug because their bodies are developing.

as shown in the picture

Pepto-Bismol affects their health in different ways depending on their condition. People with kidney or liver disease may take longer to eliminate the drug due to impaired body function. People with gastrointestinal problems may take longer to clear the drug due to slower transit times.

body structure

Physical parameters such as weight and height can affect how long Pepto-Bismol stays in the body. People who weigh a lot may take longer to eliminate the drug than people who weigh less.

food and drinks

Eating and drinking Pepto-Bismol can affect how long it stays in your system. Eating foods that contain Pepto-Bismol can decrease the dose of the medicine while drinking alcohol can increase the effectiveness of the treatment and increase side effects.

Half-life of Pepto-Bismol

The half-life of a drug is the time it takes the body to eliminate half of the drug. Pepto-Bismol has a half-life of approximately 12-24 hours. That is, half the dose is eliminated from the body after 12-24 hours.

How long does Pepto-Bismol stay in the system?

The effects of Pepto-Bismol usually last 4 to 6 hours. However, it may take 24 to 48 hours for the drug to completely clear from the body. The drug is metabolized in the liver and excreted through the kidneys and feces. How long it takes to stop taking the medicine depends on the factors listed above, your age, medical condition, and the dose of the medicine.

Pepto-Bismol (bismuth subsalicylate) takes 30 minutes to an hour to start working and relieves diarrhea, stomach pain, and nausea.

Pepto-Bismol, sometimes called “the pink stuff,” is a safe and effective over-the-counter (OTC) medication for short-term use. Side effects are usually mild and include darkening of the tongue, dark stools, and constipation. More serious side effects may occur but are rare.

This article describes Pepto-Bismol, how it works, and possible side effects.

The scientific name for the active ingredient in Pepto-Bismol is bismuth subsalicylate.

Bismuth is a mineral that has antibacterial, antacid, and antidiarrheal properties.

Subsalicylate is in the same class as aspirin.

Active ingredient in Pepto-Bismol;

Stools become more consistent as the amount of fluid taken in from the bowel increases

reduce inflammation

Soothes intestinal spasms

Reduce the number of pathogens and viruses

reduce hyperacidity

Pepto may take 30 minutes to an hour to “start”. If there is no relief at that time, do not take another dose right away. Follow the dosing directions given on the product packaging.

When to call your healthcare provider

Call your healthcare provider and stop taking Pepto-Bismol immediately if you: 1


Diarrhea for more than two days

Severe vomiting

High fever

Any allergic reaction

If you have overdosed or have severe symptoms, call an ambulance immediately.

Why is Pepto stool black?

Before taking Pepto-Bismol

Pepto-Bismol should not be taken for more than two days. Not a good choice for people with chronic diarrhea, heartburn, or acid reflux.

Talk to your healthcare provider about taking Pepto-Bismol before taking it, as it may interact with other medications you are currently taking.


Pepto-Bismol is an oral medication that comes in liquid, tablet, or chewable form. Carefully follow the instructions on the product package and instructions for use.

Do not use this medicine for more than two days.


Take liquid Pepto-Bismol using the measuring cup provided. (one serving equals one cup)

If you lose your medicine cup, check the label for formula strength. This will determine how much you should take:

Initial concentration: 30 ml (ml).

Additional: 15 ml

Pepto anti-diarrhea: 10 ml5

Dispense using a syringe or cup that allows you to accurately measure the medicine. Never use a spoon in the kitchen.

No more than eight doses in 24 hours 5.

Pills that can be swallowed

Take two Pepto-Bismol chewable tablets at once. Do not take more than 16 tablets in 24 hours.

Pepto Kids is available as chewable tablets. Dosage: 6 depending on the weight and age of the child

Under 24 pounds/under 2 years: Consult a health care provider.

24-27 pounds / 2 to 5 years: 1 tablet (maximum 3 tablets in 24 hours).

48-95 lbs / 6-11 years: 2 tablets (maximum 6 tablets in 24 hours).

If your child’s height and weight do not match any of the above, follow the appropriate size for your child’s weight.


Pepto-Bismol caplets come in a variety of formulations. Use only the amount indicated on the label:

Pepto-Bismol LiquiCaps: 2 capsules

Pepto Diarrhea Liquicaps: 2 capsules

Pepto-Bismol Capsules: 2 capsules

Pepto-Bismol Ultra Capsules: 1 capsule

Pepto-Bismol is an over-the-counter medicine used to relieve gastrointestinal symptoms such as nausea, diarrhea, and heartburn.

Bismuth sub-salicylic acid, which coats the lining of the stomach and intestines, reduces inflammation and kills bacteria that cause stomach infections.

Although it is effective in reducing gastrointestinal symptoms, many people want to know how long Pepto-Bismol stays in the system. It makes it clear from the body.

How to treat diarrhea?

Pepto-Bismol is commonly used to relieve diarrhea. But it relieves common indigestion symptoms. Pepto-Bismol breaks down in the body into two different substances: bismuth and salicylic acid. Different parts work in different ways. To relieve these symptoms

Bismuth acts as an antiseptic to relieve diarrhea. Removes harmful bacteria that cause stomach problems. This helps your body absorb more water from your intestines. Make the stools less watery, the amount of bismuth in the blood is very small. So it affects the stomach and intestines.

Salicylic acid is similar to aspirin. Unlike bismuth, this substance is absorbed by the body. Salicylic acid prevents diarrhea and intestinal irritation by inhibiting the enzyme (protein) cyclooxygenase (COX).

By inhibiting COX, salicylic acid reduces intestinal inflammation and slows the movement of food in the gastrointestinal tract. When you have diarrhea, moving your stool slowly will help retain lost nutrients.

in conclusion

Pepto-Bismol is a powerful over-the-counter medicine used to relieve gastrointestinal symptoms such as nausea, diarrhea, and heartburn. The duration of action and elimination from the body depends on many factors, such as dose, age, health, and body composition. Eating and drinking it is important to follow the recommended amount to avoid negative reactions. And if symptoms persist, consult a health care provider.

It’s a general problem.

Can I take Pepto-Bismol with other medications?

Before taking Pepto-Bismol with other medications, you should consult your healthcare provider as it may interact with certain medications.

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